Damon Wayans Set to Guest Star in NBC’s “St. Denis Medical” Season 3 Premiere, Reuniting With David Alan Grier

NBC’s “St. Denis Medical” is bringing back a piece of its comedy roots for its Season 3 premiere, with Deadline reporting that Damon Wayans will guest star in an episode opening the new season. The appearance is framed as a reunion of sorts, pairing Wayans with another former “In Living Color” castmate, David Alan Grier, who also appears on set for the premiere story line.

Deadline reported that Wayans will play Dr. Highland, described as a charming but pompous new doctor. The role is set within the medical drama’s ongoing ensemble framework, with the premiere positioning Highland as part of the show’s continuing look at workplace dynamics inside a hospital setting.

The casting also marks a return collaboration between Wayans and Grier, both of whom were prominent figures in the earlier sketch-comedy series “In Living Color.” Deadline’s report ties the guest-starring appearance directly to that shared television history, noting that the reunion will occur in the context of “St. Denis Medical” rather than a revival of the original sketch show.

Deadline’s report includes a first-look photo from the “St. Denis Medical” production, published alongside the announcement. The photo is labeled as related to “St. Denis Medical - Season 3,” indicating it is intended as an advance visual for the Season 3 premiere in which Highland is introduced.

Deadline’s description places the Wayans guest appearance specifically at the start of Season 3, identifying it as part of the premiere episode. That timing matters for viewers who follow the show’s season arcs, since premiere episodes typically set new relationships, introduce new characters, and establish the tone and conflicts that carry into the rest of the season.

For Wayans, the move continues a pattern of broad television work across genres. Deadline’s report cites his earlier television credits, including “My Wife and Kids” and “Lethal Weapon,” underscoring that the guest role on the medical series will add another dramatic-comedy blend to his screen résumé.

The Wayans-Grier reunion arrives as “St. Denis Medical” prepares its third season run on NBC, with the premiere episode serving as the immediate outlet for the collaboration. Additional details about how Dr. Highland fits into the hospital’s main cases and staff will likely be determined closer to the episode’s release, after the premiere’s storyline establishes the character’s relationships and responsibilities.